Abstract: In recent years, with the mining activities of mineral resources increasingly spreading to the deep part of the earth, the large deformation of surrounding rock caused by high stress in the deep part has become a major problem to be solved urgently. Mastering the drilling pressure relief technology can effectively reduce the stress concentration of roadway coal wall and provide important technical support for the stability control of surrounding rock in deep mining. Drilling pressure relief technology is one of the important means to solve the high stress concentration of coal body and prevent the occurrence of strong ground pressure. In this paper, the stress occurrence environment of coal body in 130607 working face of a mine is complex, the original rock stress is large, the anchor structure is damaged by drilling pressure relief, the support is difficult, and the surrounding rock deformation is large. Based on the data of 1702# geological borehole, the damage effect of drilling pressure relief on anchorage structure is put forward through theoretical analysis and numerical simulation. The parameters of large diameter drilling are put forward and practiced in 130607 working face.The monitoring results show that the peak stress of surrounding rock is reduced by 27.97% ~ 28.65%, the deformation of surrounding rock of roadway is effectively controlled.