Abstract: Under the influence of multiple mining in roadway, the diffusion effect of slurry in deep fine cracks of surrounding rock is not ideal, resulting in the easy expansion and development of fine cracks, and the stability of surrounding rock is further reduced.Micro-nano grouting reinforcement materials with good fluidity are prepared.By analyzing the setting time, fluidity and compressive strength of slurry, the main materials are optimized.To verify the comprehensive performance of micro-nano grouting reinforcement material, numerical simulation method was used to study the slurry diffusion law of micro-nano grouting reinforcement material.By analyzing the slurry diffusion law of different grouting pressure and different diffusion time under the fluid-solid coupling and viscosity time-varying effect, the relationship between compressive strength, initial setting time and final setting time, diffusion radius and the change of porosity and permeability of the micro-nano single component inorganic reinforced material was concluded.The industrial test on the material was conducted.